MD Anderson Cancer Center Institute Senior Research Scientist - Translational In-Vivo Biology in Houston, Texas
The primary purpose of the Institute Senior Research Scientist - Translational In-Vivo Biology is to work with a team of scientists towards discovery of novel anti-cancer compounds for the treatment of targeted patient populations. We are seeking an in vivo pharmacologist with experience in an industry-like environment to deliver broad in vivo support to manage disease modeling activities which includes a bank of patient-derived xenografts that are being used for preclinical mechanistic characterization and evaluation of new drug candidates and combinations. This role will require effective management of in vivo associate scientists, as well as strong scientific leadership and effective engagement and integration with multi-disciplinary teams.
The mission of The Center for Co-Clinical Trials (CCCT) is to integrate biological insights with drug discovery expertise to accelerate the development of innovative targeted cancer therapeutics. The CCCT is a ground-breaking translational research team that partners with world-class drug discovery scientists at the Institute for Applied Cancer Science (IACS) along with their industry-modelled in vivo pharmacology unit and state-of-the-art computational biology infrastructure. CCCT's cross-functional teams aim to deliver biological insights regarding genetic and functional contributions that influence tumor response to novel therapeutic agents or regimens. As part of the MD Anderson Cancer Center Moon Shots initiative, the capabilities of the CCCT, in concert with IACS, support the institution's academic and clinical research programs to help us reach our goal of delivering safer, more effective treatments to our patients
Salary range: Min $112,000 - Mid $140,000 - Max $168,000
JOB SPECIFIC COMPETENCIES
•Lead efforts to identify, develop and procure models to support drug development and translational activities.
•Lead effort to characterize and manage patient drive xenograft (PDX) model bank and database within CCCT for oncology drug discovery projects, Moon Shots collaborations and partnerships.
•Lead efforts to procure and utilize Genetically Engineered Mouse (GEM) and allograft models in support of translational biology efforts
•Oversee and manage preclinical trials utilizing PDX and GEM model collection
•Contribute to the implementation and utilization of ex vivo culture systems to assess novel therapeutics and combinations to inform on responder hypotheses and biomarkers
•Utilize and contribute to the management of LIMS Quick Base systems to collect and archive data
•Effectively design and execute in vivo studies to answer key biological questions in support of project teams, including target validation, establishing PK/PD/efficacy relationships for human dose predictions, and mechanism based combinations in support of clinical hypotheses.
•Contribute to the development and validation of biomarkers (PD and predictive) for translation to the clinic.
•Perform animal surgeries for model establishment, specimen collection and characterization.
•Utilize non-invasive imaging.
•Work collaboratively with colleagues from other disciplines to accelerate compound development.
•Manage in vivo work conducted externally at CROs and internally as part of corporate alliances.
•Provide mentorship, professional development, guidance and leadership to a team of dedicated associate scientists.
Required: Master's degree in one of the natural sciences.
Preferred: PhD in Pharmacology or related discipline.
Required: Eleven years of relevant research laboratory experience. With preferred degree, five years of required experience.
Preferred: Minimum of 4 years industry experience (at least 7 years preferred)
•Strong working knowledge of oncology disease processes and models.
•Experience working with mouse models of cancer to deliver in vivo pharmacology data.
•Experience in using various platforms to characterize and evaluate in vivo target and pathway modulation in support of drug discovery, including molecular profiling, histology/IHC, non-invasive imaging.
•Experience dosing animals using oral gavage, IP or IV dosing.
•Demonstrated ability for creative thinking and problem solving.
•Demonstrated ability to work in a multi-disciplinary team.
•Excellent leadership, communication and organizational skills.
•Experience in managing of a team of associate scientists is required.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html