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MD Anderson Cancer Center Institute Research Investigator - Neurodegeneration Consort in Houston, Texas

Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof.

The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium (NDC).

The NDC is a multi-institutional initiative launched to better understand the biology of neurodegenerative diseases and translate that knowledge into effective therapeutics interventions. Established in 2012 by a gift from the Robert A. and Renee E. Belfer Family Foundation, the NDC brings researchers from Baylor College of Medicine, the Massachusetts Institute of Technology and the Icahn School of Medicine at Mount Sinai together with drug discovery and development experts from MD Anderson's Therapeutics Discovery division. The mission of the NDC is to develop new medicines that will lead to a cure for Alzheimer's disease, but also to treat a variety of neurodegenerative conditions, including the neural and cognitive impairments that commonly result in cancer patients as a result of their treatment.

The Institute Research Investigator participates in cross-functional research to identify and validate novel neurodegeneration targets, and translates these findings into novel neurodegeneration therapeutic agents to benefit patients.

KEY FUNCTIONS:

•Independently proposes innovative solutions to research projects and contributes to project goals through laboratory experiments

•Assists in the integration of data to identify neuroinflammation-related genes/pathways pertinent to neurodegeneration and treatment

•Leverages knowledge in field and keeps up with literature to positively impact projects

•Works closely with research team to identify and recommend opportunities leading to the discovery of neuroinflammation related genes/pathways to further advance scientific discovery and clinical therapeutic drug development

•Experienced in cell culture - both cell lines and more complex culture systems including primary microglia cultures, co-culture systems, patient derived iPSCs

•Utilizes, as needed, siRNA, inducible shRNA, dominant negative methods, and pharmacological tools (e.g., small molecule inhibitors) to validate targets and interrogate biology

•Develop and optimize cell-based assays for PoC studies and compound testing

•Experience in cell-based assays (functional and phenotypic assays including but not limited to phagocytosis, chemotaxis, cytokine measurements, and cell signaling assays) to support target validation, and address specific questions related to target engagement and efficacy of new small molecule compounds/drug candidates

•Responsible for planning and executing experiments to achieve project goals and meet timelines

•Analyzes and interprets data and presents data at team meetings

•Performs gene expression (protein and mRNA) analysis – RNAseq, qRT-PCR, Western blotting, immunocytochemistry, ELISA, cytokine assessments

•Performs immunohistochemistry in brain slices to identify specific expression of relevant proteins following in vivo PoC experiments

Education

Required: Bachelor's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

Required: Six years experience of relevant research experience in laboratory With Master's degree, four years of required experience. With a PhD in a natural science or Medical degree, no experience required.

Preferred: Industry experience in drug discovery, neuroinflammation, neuroimmunology, neuroscience or immunology.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information

  • Requisition ID: 133960

  • Employment Status: Full-Time

  • Employee Status: Regular

  • FLSA: exempt and not eligible for overtime pay

  • Work Week: Days

  • Fund Type: Soft

  • Pivotal Position: Yes

  • Minimum Salary: US Dollar (USD) 85,000

  • Midpoint Salary: US Dollar (USD) 106,250

  • Maximum Salary : US Dollar (USD) 127,500

  • Science Jobs: No

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