MD Anderson Cancer Center Institute Associate Scientist II - Drug Metabolism and Pharmacokinetics Research Group in Houston, Texas

MD ANDERSON THERAPEUTICS DISCOVERY DIVISION

Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof.

The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.

The IACS platform is focused on discovering and developing the next generation of small-molecule targeted therapies, driven by the needs we see in our patients. The team aligns world-class drug discovery and development research with the science and clinical care for which MD Anderson is known. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.

By joining the Therapeutics Discovery Division, you have the opportunity to use your talents to make a direct impact on the lives of our patients.We are seeking a highly motivated and team-oriented individual to join our ADME/PK group to support our fast-paced drug discovery programs. The Institute Associate Scientist II will use LC-MS to characterize or quantitate in vitro and in vivo biological samples of small molecule drug candidate compounds. Ideal candidate will have solid chemistry background and /or LC-MS instrument experience obtained from an internship or work experience in addition to required education.

KEY FUNCTIONS

  1. Under minimal supervision, process plasma, tumor and any other tissue samples using liquid handling automation systems or solid phase extraction (SPE) for liquid chromatography mass spectrometry (LC-MS) analysis.

  2. Conduct in vitro ADME incubation assays such as plasma stability assay, microsomal stability assay, hepatocyte incubation, and plasma-protein binding assay.

  3. Conduct LC-MS/MS method development of new small molecule drug candidate compounds.

  4. Use LC-MS for sample analysis, data acquisition, data analysis, and generate final bioanalytical reports.

  5. Conduct routine LC-MS instrument maintenance and performance check.

  6. Employ safe lab practices.

  7. Maintain research records and laboratory notes.

  8. Participate in integrated drug discovery research project teams.

Education

Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Preferred: Master's degree in Medicinal Chemistry, Organic Chemistry, Biochemistry, Pharmacology, Chemistry, Biology or related field.

EXPERIENCE

Experience

Required: Eighteen months of relevant research laboratory experience. With preferred degree, no required experience.

Preferred: 2 years' experience in Medicinal Chemistry, Organic Chemistry, Enzymology, Analytical Chemistry, Cell Culture or Pharmacology. Capable of doing routine instrument (LC-MS) maintenance.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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Additional Information

  • Employee Status: Regular

  • Minimum Salary: US Dollar (USD) 48,000

  • Midpoint Salary: US Dollar (USD) 67,000

  • Maximum Salary : US Dollar (USD) 86,000

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